2-(2-chloro-4-fluorophenyl)-2,2-difluoroacetic acid - Names and Identifiers
2-(2-chloro-4-fluorophenyl)-2,2-difluoroacetic acid - Physico-chemical Properties
Molecular Formula | C8H4ClF3O2
|
Molar Mass | 224.56 |
Density | 1.550±0.06 g/cm3(Predicted) |
Boling Point | 289.3±35.0 °C(Predicted) |
pKa | 0.75±0.10(Predicted) |
2-(2-chloro-4-fluorophenyl)-2,2-difluoroacetic acid - Introduction
2-(2-choro-4-fluorophenyl)-2,2-difluoroacetic acid is an organic compound with the chemical formula C8H4ClF3O2.
Nature:
-Appearance: White crystalline solid
-Melting point: 114-116 ° C
-Boiling point: 220-222 ° C
-Density: 1.6g/cm3
-Solubility: It is soluble in solvents, such as ethanol and ether.
Use:
2-(2-chloro-4-fluorophenyl)-2,2-difluoroacetic acid has some important uses:
-As a pharmaceutical intermediate: It can be used to synthesize drugs, pesticides and other biologically active compounds.
-Used in Organic Synthesis: It can be used as a substrate or reagent for organic synthesis reactions, such as the fluorination reaction of olefins and the synthesis reaction of esters.
Method:
2-(2-chloro-4-fluorophenyl)-2,2-difluoroacetic acid can be synthesized by the following steps:
1. Reaction of 2,2-difluoroacetic acid with chloro-4-fluorobenzene in a suitable solvent yields 2-(4-chloro-4-fluorophenyl)-2,2-difluoroacetic acid.
2. The product obtained in step 1 is reacted with chloroacetic acid under appropriate conditions to generate the final product 2-(2-chloroo-4-fluorophenyl)-2,2-difluoroacetic acid.
Safety Information:
When using, handling and storing 2-(2-chloro-4-fluorophenyl)-2,2-difluoroacetic acid, the following safety precautions are required:
-Avoid contact with skin and eyes: It may be irritating to skin and eyes.
-Avoid inhalation or ingestion: During operation or handling, it is necessary to maintain good ventilation conditions and avoid inhalation or ingestion.
-use of personal protective equipment: when handling, should wear appropriate protective gloves and glasses and other equipment.
-Storage safety: Store it in an airtight container, away from fire and oxidizing agents.
Please note that this information is for informational purposes only. When using or handling chemicals, follow proper laboratory practices and safety practices, and follow relevant regulations and guidelines.
Last Update:2024-04-09 19:05:55